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OSCE question 7.

Marks

A 52 year old patient presents with a complaint of post-menopausal bleeding.

See also MCQ1, question 21. 

1.  What is the definition of post-menopausal bleeding?

Genital tract bleeding occurring after 12 months after the menopause.

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2.  What issues will you particularly cover in taking the history? List 4.

When did the bleeding start? How often has it occurred? How long has it lasted? Have there been any associated symptoms e.g. discharge? Has there been any obvious explanation e.g. trauma or using a ring pessary for prolapse control? Is she taking any drugs that might cause bleeding e.g. HRT & anticoagulants? Is there any factor that might increase the risk of malignancy e.g. taking Tamoxifen, previous genital tract cancer or pre-cancer, family history of genital tract cancer?

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3.  What will you look for on pelvic examination? List 3 things.

Benign or malignant conditions causing the bleeding. Vulval ulceration. Atrophic vaginal changes. Vaginal ulceration. Foreign body in the vagina: pessary, inserted object. Cervical polyps, “erosions” or possible malignancy. Pelvic masses - ? ovarian tumour. Vaginal infection, e.g. trichomonal or candidal, is mentioned in some books, but I must say that it rarely, if ever, occurs in my experience. Up to 15% of ovarian cancer presents with postmenopausal bleeding, so the ovaries must never be overlooked.

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4.  What further investigations might be appropriate? List 3.     

Cervical smear. This will help exclude cervical cancer, though if the cervix looks at all odd, colposcopy and biopsy are indicated. Occasionally atypical glandular cells are found arising from the endocervix, endometrium, ovary or even the tube, though the latter two are rare. Ultrasound, usually transvaginal, to measure endometrial thickness and exclude pelvic tumours. If the endometrium is < 4mm., the risk of hyperplasia or malignancy is small. (Lots of patients present with a single scanty bleed. The associated risk of malignancy is tiny. If the scan shows the endometrium to be thin, I usually give them the option of no further investigation unless the bleeding recurs. They all take it!) The scan may also suggest benign endometrial pathology such as submucous fibroids or polyps that could explain the bleeding. Pipelle endometrial sampling, outpatient / inpatient hysteroscopy.

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5.  If clinical examination is normal, what advice will you give her about possible serious pathology?

The College quotes a 9% risk of malignancy associated with postmenopausal bleeding. I think this is on the high side, but you can still reassure the patient that the risk of serious disease is <10%. In addition, most of the serious conditions, such as endometrial hyperplasia and cancer are treatable though you cannot offer guarantees of cure.

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