1.
The following statements about sickle cell disease are true:
| a. | it is most common in women of Mediterranean origin. | |
| b. | the red cells mainly contain HbF. | |
| c. | maternal and perinatal mortality rates are increased. | |
| d. | it is an autosomal dominant condition. | |
| e. | sickling crises are more common in pregnancy and the puerperium. | |
| f. | the condition produces severe chronic anaemia, with Hb values usually < 9 gm.%. | |
| g. | acute infection is the commonest cause of severe crises in pregnancy. | |
| h. | general anaesthesia carries no extra hazard to these patients. | |
| i. | patients often have haematuria and reduced ability to concentrate urine. | |
| j. | blood transfusion to increase the proportion of HbA is standard management in pregnancy. | |
| k. | the baby of an affected mother will be born with severe anaemia and require early exchange transfusion. | |
| l. | HbS differs from HbA in the amino acids of the b-globin chain. | |
| m. | HbS precipitates in conditions of low oxygen tension. | |
| n. | bone pain is common in pregnancy. | |
| o. | 20%
of the affected ethnic group are carriers in the |