MCQp4a7

7. 46 XX is associated with:

a.	constitutional hirsutism.	True
b.	hydatidiform mole.	True
c.	Turner’s syndrome.	False
d.	Edward’s syndrome.	False
e.	Testicular feminisation syndrome.	False
f.	Klinefelter’s syndrome.	False
g.	bilateral renal agenesis.	False
h.	cleft lip and palate.	False
i.	muscular dystrophy.	False
j.	Tay Sach’s disease.	False
k.	Congenital adrenal hyperplasia.	False
l.	Polycystic ovary syndrome.	True
m.	Sheehan's syndrome.	True

Constitutional hirsutism just means that you are naturally hairy.

Hydatidiform mole is usually 46XX.

The chromosome material is all paternal - bizarre but true.

For fuller details, see MCQ 6, question 19.

Turner’s syndrome is 45XO - see MCQ 4, question 24 and MCQ 5, question 14.

Testicular feminisation is 46XY (MCQ 1, question 34) and Klinefelter’s is 47XXY (MCQ 5, question 12).

Edward’s syndrome is trisomy 18 (MCQ 2, question 35).

Bilateral renal agenesis is Potter’s syndrome – see MCQ4, question 5.

Cleft lip and palate are thought to be due to multiple gene influences, but occur in the rare Patau’s syndrome.

Muscular dystrophy only affects boys.

Tay Sach’s is an autosomal recessive condition. (See MCQ 10, question 21.)

Congenital adrenal hyperplasia, also known as adreno-genital syndrome can affect boys and girls. (See MCQ 6, question 23.)

Polycystic ovary syndrome is dealt with in questions 9 and 12 in this paper.

Sheehan’s syndrome is where the pituitary is damaged by hypotension resulting from obstetric haemorrhage. (See MCQ8, question 11.)